Journal article
Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults
Michael G Slee, Stephanie R Rainey-Smith, Victor L Villemagne, James D Doecke, Hamid R Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M Laws, Colin L Masters, Christopher C Rowe, Ralph N Martins, Kirk I Erickson, Belinda M Brown
Alzheimer's and Dementia | Wiley Open Access | Published : 2024
DOI: 10.1002/alz.13556
Abstract
INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. RESULTS: PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = ..
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Funding Acknowledgements
Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Science and Industry Endowment Fund; Dementia Collaborative Research Centres; Victorian Government's Operational Infrastructure Support program; Australian Alzheimer's Research Foundation; National Health and Medical Research Council; Yulgilbar Foundation